https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52050 1.1 million by 2058.2 The annual care costs are estimated to increase from $9.1 billion in 2017 to A$24.1 billion by 2056.3 Currently, there is a lack of a single valid and reliable data source for dementia identification. Welberry et al. recently demonstrated the feasibility of linking large population-based cohorts to administrative datasets to identify dementia cases at different stages of their trajectory.4 The Addressing Dementia Through Analysis of Population Traits and Risk Factors (ADAPTOR) project links data from a large Australian cohort study (followed up for 15 years) to various administrative health datasets. While the project links the same cohort study (the Sax Institute’s 45 And Up Study) and administrative datasets for dementia identification, it expands on Welberry et al.’s study by extending the data cut-off period from June 2014 to June 2018; including additional datasets and participants aged between 45–54 years; and stratifying data by sex and age group. The ADAPTOR project estimates dementia incidence, investigates the association between risk factors and incidence, and models the impact of modifiable risk factor reduction (e.g. increased physical activity, reduced alcohol consumption) on population-level dementia incidence. This paper presents preliminary findings from the project on sex and age-specific incidence of dementia and presents the most common data sources for dementia identification.]]> Wed 27 Sep 2023 15:29:45 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45150 Wed 26 Oct 2022 19:29:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45194 n = 294, 95–106 years; controls: n = 1105, 55–65 years) by assessing their polygenic risk scores (PRS) based on a genome wide association study (GWAS) threshold of p < 5 x 10⁻⁵. PRS were constructed using GWAS summary data from two exceptional longevity (EL) analyses and eight cardiovascular-related risk factors (lipids) and disease (myocardial infarction, coronary artery disease, stroke) analyses. A higher genetic risk for exceptional longevity (EL) was significantly associated with longevity in our sample (odds ratio (OR) = 1.19–1.20, p = 0.00804 and 0.00758, respectively). Two cardiovascular health PRS were nominally significant with longevity (HDL cholesterol, triglycerides), with higher PRS associated with EL, but these relationships did not survive correction for multiple testing. In conclusion, ELL individuals did not have significantly lower polygenic risk for the majority of the investigated cardiovascular health traits. Future work in larger cohorts is required to further explore the role of cardiovascular-related genetic variants in EL.]]> Wed 26 Oct 2022 14:27:30 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24759 -11). The results were replicated in an independent cohort, the Hunter Community Study (p < 0.002) (n = 313). Conditional and joint analysis (COJO) confirmed the association of the chromosomal 17 region with ApoH levels. The set of independent SNPs identified by COJO explained 23% of the variance. The relationships between the top SNPs and cardiovascular/lipid/cognition measures and diabetes were assessed in Sydney MAS, with suggestive results observed for diabetes and cognitive performance. However, replication of these results in the smaller OATS cohort was not found. This work provides impetus for future research to better understand the contribution of genetics to ApoH levels and its possible impacts on health.]]> Wed 15 Dec 2021 16:09:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:15187 Wed 11 Apr 2018 15:11:57 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20161 Tue 24 Aug 2021 14:24:28 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54564 Tue 14 May 2024 13:54:22 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34724 Thu 17 Feb 2022 09:27:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36726 ɛ4/ɛ3> ɛ3/ɛ3> ɛ2/ɛ3> ɛ2/ɛ2). The greatest variation in lipids was related to the ɛ2 isoform, where various lysophosphatidylcholines and all phosphatidylethanolamine (PE) subclasses were elevated relative to ɛ3/ɛ3 and ɛ4 carriers. APOE ɛ4 carriers had reduced phosphatidylinositol relative to ɛ3/ɛ3 and ɛ2 carriers. Logistic regression revealed that ɛ2 carriers were at least 4 times higher odds of being in the highest tertile of PE lipid level relative to ɛ3/ɛ3. The elevation in PE and other phospholipids in ɛ2 carriers may indicate the protective effect of ɛ2 is linked to these phospholipids. Additionally, high baseline PE in cognitively normal participants predicted protection against cognitive decline six years later. Our data suggest substantial modulation of plasma lipids by APOE genotype and therefore indicates possible lipid targets and pathomechanisms involved in AD risk.]]> Thu 02 Jul 2020 09:10:42 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1462 Sat 24 Mar 2018 08:28:07 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10285 Sat 24 Mar 2018 08:09:08 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18298 Sat 24 Mar 2018 08:04:27 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17996 Sat 24 Mar 2018 07:56:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21021 N = 2088) and the Sydney Memory and Ageing Study (Sydney MAS, N = 541). Genotyping was undertaken using Affymetrix microarrays with imputation to HapMap2. Analyses were performed using linear regression. No genome-wide significant results were observed in HCS nor were any of the top signals replicated in Sydney MAS. Gene-based analyses in HCS identified two significant genes (ZNF295, C2CD2), but these results were not replicated in Sydney MAS. One out of eight SNPs previously associated with GS, rs550942, located near the CNTF gene, was significantly associated with GS (p = 0.005) in the HCS cohort only. Study differences may explain the lack of consistent results between the studies, including the smaller sample size of the Sydney MAS cohort. Our modest sample size also had limited power to identify variants of small effect. Our results suggest that similar to various other complex traits, many genetic variants of small effect size may influence GS. Future GWAS using larger samples and consistent measures may prove more fruitful at identifying genetic contributors for GS in middle-aged to older adults.]]> Sat 24 Mar 2018 07:50:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:27185 Sat 24 Mar 2018 07:31:41 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28945 Sat 24 Mar 2018 07:31:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:30671 95% in both groups. GPs and their patients both found the GPCOG to be an acceptable cognitive assessment tool. The dementia cases missed via case-finding were younger (p = 0.024) and less cognitively impaired (p = 0.020) than those detected. Conclusion: There is a very limited benefit of screening for dementia, as most people with dementia could be detected using a case-finding approach, and considerable potential for social and economic harm because of the low PPV associated with screening.]]> Sat 24 Mar 2018 07:29:36 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28987 Sat 24 Mar 2018 07:29:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:26028 Sat 24 Mar 2018 07:26:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22195 Sat 24 Mar 2018 07:16:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50640 Mon 31 Jul 2023 16:34:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35059 Mon 17 Jun 2019 11:20:45 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:33670 Mon 01 Jul 2019 09:50:58 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51516 Fri 08 Sep 2023 12:05:45 AEST ]]>